Fatto generale: 4281 is a number for which we're missing a fact (submit one to numbersapi at google mail!).
Fatto matematico: 4281 is an unremarkable number.
Trivia: 4281 is an unremarkable number.
Data storica: September 20th is the day in 1871 that Bishop John Coleridge Patteson is martyred on the island of Nukapu, a Polynesian outlier island now in the Temotu Province of the Solomon Islands.