Fatto generale: 4159 is a number for which we're missing a fact (submit one to numbersapi at google mail!).
Fatto matematico: 4159 is 4^{5} + 1^{5} + 5^{5} + 9.
Trivia: 4159 is an uninteresting number.
Data storica: May 21st is the day in 1554 that a royal Charter is granted to Derby School as a grammar school for boys in Derby, England, by Queen Mary I.